Qubes OS: A reasonably secure operating system
www.qubes-os.org
Qubes is a security-oriented, free and open-source operating system for personal computers that allows you to securely compartmentalize your digital life.

With all the supply chain attacks in the Linux ecosystem, isn’t the natural solution to move to full application sandboxing?

Flatpacking is great but not all applications support it.

Is it too much of a hassle?