wait, what do you mean “integrating it into workflows”. this juicero of outsourcing won’t work as advertised and it’s probably cheaper and less prone to fucking up to hire a couple of southeastern asians or eastern europeans. as long as business is selling of these juiceros, they’ll be fine as long as they can find suckers. these suckers, tho, might be in trouble even before openai goes under for unrelated reasons
oh but that’s not my problem, and those who got in that very stupid position deserve every last bit of it
as long as you can mark it up and as long as the charade lasts, and as long as there’s someone willing to pay, this will make money. when spicy autocomplete provider collapses just pack your bags and leave
blockchain targeted libertarian post-goldbug pro-cyberpunk-dystopia fuckheads, llms target management types (you will replace workers with machines!), maybe that’s why
this might be fallout from tariffs, some went in on saturday iirc
perun weighs in on tariffs and guesses what might come next https://www.youtube.com/watch?v=nVZ1lcw2bVU
some things perun notes that i hadn’t because i haven’t followed the entire situation closely: that trade deficit calculation uses goods only, not services, and this is most of what sv exports; eu might retaliate against sv oligarchs specifically. also we’re in times where it’s necessary to pull up american govt pages from internet archive to make a point. fun. also chatbot-cooked policy looks suspiciously like chatbot solution to a entry level econ course toy problem with loads of very unusual assumptions, which are discussed too.
maybe stable genius tries to bring american wages closer to global average
it must be comforting to think that there’s some bigger plan, and they can’t possibly be this stupid and incompetent
(by now i do think that they’re this stupid and incompetent, and if it appears that there’s no plan going forward it is because there was never one. they’re malicious, see Zelensky visit, and can plan perhaps a week in advance, but nowhere near sophisticated enough to come up with this)
none of these are complete without posadism
So far I’ve only read Harry Potter and The Methods of Rationality, but can say it is an excellent place to start.
beware the man of one book
Who does this appeal to? It’s nonsense.
the fake nerds of silicon valley of course
on reddit, the website plays you
have rules never clearly explained, get banned pretty much immediately. a taste of real reddit experience™ even that i’ve never got banned sitewide (only on r/conservative) i guess you win if you touch grass or quit
death of millions for profit - solid business practice, congratulations and see you again at next shareholder meeting
I’m with the old man on this one. Antibodies can clear out amyloid and still it has no effect on progression of disease, amyloid secretion can be blocked upstream (like with small molecule protease inhibitors) and it still has no effect. Maybe this one hits something off-target, or maybe that effect is not even real, or maybe it’s some sort of statistical artifact. You’d stumble upon some false positive after trying so many times.
Aducanumab is dead in the water, trials shown no effect and it was abandoned by Biogen. This one is about lecanemab. Both have massive problems with brain edema and microhemorrages, which probably means these are not suitable for actual use. But don’t worry, they already have received their reward - FDA wanted to have something, anything to show up for Alzheimer and Biogen cashed in when stock price went up
think cold fusion, or EmDrive, or string theory
That’s a weird set - cold fusion or EmDrive can be tested and their physical principles are falsifiable - and they were - but string theory is different, because it’s not falsifiable.
If it’s marginally but truly effective,
That if makes some mighty heavy lifting here. I think that amyloid hypothesis is closer to cold fusion than to string theory in that it had already a couple of fatal experimental refutations thrown at it, but people still shove effort this way because there’s nothing else/copium/sunk cost combination
that’s just internet dementia
has he? where?
Derek Lowe has seen it coming years ago https://www.science.org/content/blog-post/lecanemab-and-alzheimer-s-more-data
But let’s stipulate that the result is real, for the sake of argument. That takes us into the very contentious question of real-world utility. As the NEJM paper says, “A definition of clinically meaningful effects in the primary end point of the CDR-SB score has not been established”. Clinicians are already disagreeing over whether the difference between lecanemab and placebo is something that would even be noticeable. That last link features a quote of Madhav Thambisetty, a neurologist at the National Institute on Aging: “From the perspective of a physician caring for Alzheimer’s patients, the difference between lecanemab and placebo is well below what is considered to be a clinically meaningful treatment effect”. This is not an uncommon take.
And that leads to question 3. A constant problem with these anti-amyloid antibody ideas is the complication of brain edema, an inflammation response that can be serious trouble. The term of the art is “amyloid-related imaging abnormalities with edema or effusions”, ARIA-E. This latest trial kept a constant watch for this, as well it should have, and any such trial also has to keep in mind the possibility of “functional unblinding” as any incidents develop. ARIA-E was noted in 0.8% of the treatment group (and in none of the placebo patients, naturally). Overall, adverse events that were enough to lead to patient discontinuation in the trial occurred in 6.9% of the treatment group and 2.9% of the placebo group. Most seriously, two patients in the treatment group have died from what could well be treatment-related vascular issues
There was also earlier anti-amyloid antibody that got approved despite showing no benefit at all https://www.science.org/content/blog-post/they-don-t-know
these are called bribes