

in my country it used to be like this for 50 years, you get flat rate per day, counted up to fractions of day, separately for accomodation and food + everything else. you only have to keep transportation tickets


in my country it used to be like this for 50 years, you get flat rate per day, counted up to fractions of day, separately for accomodation and food + everything else. you only have to keep transportation tickets


behold, disruption
i don’t mean beta-oxidation, it’s just a series of separated normal reactions. i mean something like this: when first learning about ketones, you might learn about aldol condensation, which has enol as a nucleophile and another carbonyl as electrophile. at some other point you might learn about strecker reaction, which has iminium ion as electrophile and cyanide as nucleophile. but really, what you can do is mix and match, and you can pair enolizable ketone and iminium (mannich reaction) or carbonyl and cyanide (cyanohydrin formation) and then generalize, for example you don’t need strictly ketone for mannich, you can use any electron rich conjugated system like malonate or nitroalkane anion (henry reaction) or phenol or indole. to figure this out you need to study mechanisms. these last two are usually treated as variants of friedel-crafts reaction, but really categories like this are fake
and to get that right, you need to know how these reactive intermediates look like, how reactive they are, what influences their stability which means that ochem starts with discussion of carbocations, carboanions, radicals, their shapes and orbitals involved, hyperconjugation, solvent effects and the like. and then first reactions taught are sn1/sn2, because these showcase these fundamentals nicely, and from there, it’s about introduction of more compound classes
we only had synthons introduced during lecture at around 4th year, and only for ochem path, it’s not doing a lot at that point and imo would have much more impact right after ochem intro course


there was also yolo minneapolis, or whatever was his name i don’t think he was relevant since covid
i always thought that the idea of synthons should be taught early on https://en.wikipedia.org/wiki/Synthon
i’d say it’s more important to learn mechanisms because this way you can notice these patterns of reactivity easier. at some point you’d only get new reactions that are really just pieces of other reactions you know put in a new way
there’s zero reason to make chart like this, it’s both barely comprehensible and touching surface level stuff only (where are palladium couplings for one)


ahem. h5n1 for ferrets was probably made because ferrets turn out to have immune systems similar enough to humans, in that they do get (common strains of) flu and transmit it by sneezing, that is ferrets are good model organisms for flu vaccine development. so if regular ferrets don’t catch h5n1, then you have to modify either virus or ferret because otherwise it won’t work. it’s not some random virologist deciding to wage biological war against fuzzy noodle critters


if only, maupin spoke on a conference in teheran next to dugin and publishes his books. the layer of red paint on brown couldn’t be possibly thinner. see also: jackson hinkle, maga-communism. i wish everyone involved nice tuberculosis infection in damp ukrainian prison


It’s funny (read: farcical) to see a person posing as leftist say they are “pro-AI” but “anti-AI industry”.
not looking to start instance war or anything btw
iirc one of db0 admins is of this opinion which boils down to, in their case, that they’re pro-ai but only if self-hosted (ie “yes, i’m pro-ai, just not pro-the kind of ai that is actually used in 99.9% ai output”). they join it with pro-piracy and anarchist positions and it’s part of the reason why ai content is allowed on that instance. iirc it’s not even consensus among their other admins


you can just put a flywheel on synchronous machine and it also works, especially where you have infra left over after coal plant shutdown or something similar


they might have done it this way because hydro, nuclear (or any steam turbine based) or gas (or any gas turbine based) generation is rotating generation, which helps to stabilize grid in a way that solar or (some of) wind power doesn’t. on top of that, many of solar installations won’t output energy without mains (grid-followers). getting rid of that would be a is a complex problem that would require infrastructure buildout and policy changes


why is aweful systemes broken today? does it depend on aws somehow?


i heard from reliable source (ed zitron) that he has one


tldr is that anthropic spent on aws only 2x their revenue in 2024, spent on aws approx the same as their revenue in 2025 up to september, and they also pay unknown amount but known to be a lot for google cloud, on top of everything else like salaries and who the fuck knows what else
you’re not missing anything, it’s an unhinged tradeoff that you do because you need to conserve copper for brass casings because nazis are in calais, there’s zero reason to do this today. apparently it’s still allowed in uk for some unthinkable reason but i haven’t heard of it anywhere else. yes, single fuse *per ring is used, rated at double what it would be in star/radial circuit
you don’t even need a fault, sufficient asymmetry in ring geometry or load distribution already will cause this problem
yeah that’s what separate fuses for separate branches of circuit are for, all in one central box because where else are these supposed to be. if your lamp is wired with 6A-rated wire then that branch should be fused with 6A fuse, which on its own is unhinged because usually much thicker wires are used anyway
These things are under high voltage, so no. And then there’s several kg of mercury inside
i don’t think so, it’s like megatons to megawatts but stupider, instead of using up uranium from adversary they want to use up their own plutonium, while also having policies against spent fuel reprocessing (for alleged nonproliferation reasons, which is patently bullshit, power generation was straight up cheaper this way because new uranium is cheaper than reprocessing and use of mox. some other countries (at minimum ru, fr, in, pk, jp, cn, il) do reprocessing as a matter of national security/energy independence/hedge against future shortages of uranium). also this requires recertification of reactors for mox use, which won’t always work or else only part of uranium can be replaced, and if it’s for smr, then there’s gonna be a lot of plutonium in there, and it all starts with handing plutonium to motherfucking sam altman, for only a slight chance of any positive results
i see it more as current administration ripping copper wiring from walls than anything else tbh