In my experience so far, Lemmy.one has been the best. Fast, safe, responsive, and has a friendly community.

Edit: With a huge flaw that I discovered, that it does not allow you to downvote. I mean you can downvote the same post from other instances. Anyway this led me to lemm.ee. I don’t know if that would be the final one I stick to, but so far it’s looking good.