Idk some see it as using it in excess due to body image issues in Hollywood but a lot it seems like its always a thinly veiled shot at the body positive movement whenever I see this mentioned. The South park episode I’m sure helped fuel this. Hell of a lot of moralizing over ozempic in general and people not losing weight the “right way”. 
As society at large is hyper-optimized to constantly measure the size of women, especially celebrity women, we are simply (more) ignorant to when a man’s body changes shape. We also categorize eating disorders and the bodyshapes that are attached to it as feminine, so Ozempic continues to reinforce that by marketing itself to women and the users we will notice the most are going to be women.
I think there’s also some element of how men are seen to be “working” for their bodies even when roiding up, whereas GLP inhibitors are seen as “instant”, reinforcing misogynist ideology that suggests men work for their goals and women want instant gratification.