Fun fact: it actually takes a while to get addicted to opium
You also have to have some kind of special receptor to get euphoria from it, which I lack.
You should probably stop spreading misinformation. No drugs cause immediate physical dependence but every dose changes your body and causes reenforcement learning. It doesn’t really make sense to try and find the dose that gets you addicted, it it when you get crippling withdrawls? Or you know all the doses that lead up to that.
Opium is a crude extract (the latex of papaver somniferum, aka breadseed poppy) containing many alkaloids but the primary one that causes pleasure is morphine. Morphine interacts with the mu opiod receptor, activating it. It’s possible you might lack it but I am not sure you would work properly, it’s very fundamental and regulates so many low level processes (hence why you can stop breathing or get lethally constipated). If you lack it, almost nobody else does.
My brother is opioid resistant and has constant back pain. What he really needs is fentanyl but can’t get it due to widespread abuse. Same reason you can’t get Ambien after Tiger Woods took it and drove his Rolls-Royce into a ditch. The cops found him sound asleep with the engine running.
Resistance is a real thing, but that’s not lacking the receptor. It can be caused by loads of shit from small mutations reducing binding affinity, metabolic differences decreasing halflife, or weird brain shit that reduces the analgesia because you just process pain differently.
Firstly cheers for like slopjacketting me, idk why you think that I’m just writing what I know dickhead.
Secondly you said you don’t have the receptor, and continuing on from that you said your brother has resistance. I was trying to be polite to you by giving you an out from being stupendously wrong by opening the “Oh you might be confused by what resistance entails and how it’s different from lacking the receptor” door.
You should probably stop spreading misinformation. No drugs cause immediate physical dependence but every dose changes your body and causes reenforcement learning. It doesn’t really make sense to try and find the dose that gets you addicted, it it when you get crippling withdrawls? Or you know all the doses that lead up to that.
Opium is a crude extract (the latex of papaver somniferum, aka breadseed poppy) containing many alkaloids but the primary one that causes pleasure is morphine. Morphine interacts with the mu opiod receptor, activating it. It’s possible you might lack it but I am not sure you would work properly, it’s very fundamental and regulates so many low level processes (hence why you can stop breathing or get lethally constipated). If you lack it, almost nobody else does.
Thank you for pushing back on this.
My brother is opioid resistant and has constant back pain. What he really needs is fentanyl but can’t get it due to widespread abuse. Same reason you can’t get Ambien after Tiger Woods took it and drove his Rolls-Royce into a ditch. The cops found him sound asleep with the engine running.
Resistance is a real thing, but that’s not lacking the receptor. It can be caused by loads of shit from small mutations reducing binding affinity, metabolic differences decreasing halflife, or weird brain shit that reduces the analgesia because you just process pain differently.
If I wanted AI slop I’d ask myself, you don’t have to copy-paste. Humans only.
Firstly cheers for like slopjacketting me, idk why you think that I’m just writing what I know dickhead.
Secondly you said you don’t have the receptor, and continuing on from that you said your brother has resistance. I was trying to be polite to you by giving you an out from being stupendously wrong by opening the “Oh you might be confused by what resistance entails and how it’s different from lacking the receptor” door.
No good dead goes unpunished I guess.