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☆ Yσɠƚԋσʂ ☆@lemmy.ml to Science@lemmy.mlEnglish · 2 years ago

Study finds coffee inhibits SARS-CoV-2

cellandbioscience.biomedcentral.com

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Study finds coffee inhibits SARS-CoV-2

cellandbioscience.biomedcentral.com

☆ Yσɠƚԋσʂ ☆@lemmy.ml to Science@lemmy.mlEnglish · 2 years ago
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Coffee as a dietary strategy to prevent SARS-CoV-2 infection - Cell & Bioscience
cellandbioscience.biomedcentral.com
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Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-19 severity. However, the mechanisms of coffee for the reduction of COVID-19 risk are still unclear. Results Here, we identified that coffee can inhibit multiple variants of the SARS-CoV-2 infection by restraining the binding of the SARS-CoV-2 spike protein to human angiotensin-converting enzyme 2 (ACE2), and reducing transmembrane serine protease 2 (TMPRSS2) and cathepsin L (CTSL) activity. Then, we used the method of "Here" (HRMS-exploring-recombination-examining) and found that isochlorogenic acid A, B, and C of coffee ingredients showed their potential to inhibit SARS-CoV-2 infection (inhibitory efficiency 43–54%). In addition, decaffeinated coffee still preserves inhibitory activity against SARS-CoV-2. Finally, in a human trial of 64 subjects, we identified that coffee consumption (approximately 1–2 cups/day) is sufficient to inhibit infection of multiple variants of SARS-CoV-2 entry, suggesting coffee could be a dietary strategy to prevent SARS-CoV2 infection. Conclusions This study verified moderate coffee consumption, including decaffeination, can provide a new guideline for the prevention of SARS-CoV-2. Based on the results, we also suggest a coffee-drinking plan for people to prevent infection in the post-COVID-19 era.
  • Chais@sh.itjust.works
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    2 years ago

    So between daily coffee and weekly cannabis consumption I should be well protected. Not to mention the vaccination. So why did I catch that shit last year??

    • EmergMemeHologram@startrek.website
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      2 years ago

      Because 10% more protection does not mean 100% safe.

      • Chais@sh.itjust.works
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        2 years ago

        I wasn’t being serious, in case that wasn’t obvious. But thanks for the clarification.

        • EmergMemeHologram@startrek.website
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          2 years ago

          I’ve lost my sarcasm detector when it comes to Covid 😑

          • Chais@sh.itjust.works
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            2 years ago

            That’s understandable.

    • Pascal Wicht@mastodon.social
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      2 years ago

      @Chais @yogthos I was asking myself the same 🤣

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