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☆ Yσɠƚԋσʂ ☆@lemmy.ml to Science@lemmy.mlEnglish · 2 years ago

Study finds coffee inhibits SARS-CoV-2

cellandbioscience.biomedcentral.com

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Study finds coffee inhibits SARS-CoV-2

cellandbioscience.biomedcentral.com

☆ Yσɠƚԋσʂ ☆@lemmy.ml to Science@lemmy.mlEnglish · 2 years ago
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Coffee as a dietary strategy to prevent SARS-CoV-2 infection - Cell & Bioscience
cellandbioscience.biomedcentral.com
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Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-19 severity. However, the mechanisms of coffee for the reduction of COVID-19 risk are still unclear. Results Here, we identified that coffee can inhibit multiple variants of the SARS-CoV-2 infection by restraining the binding of the SARS-CoV-2 spike protein to human angiotensin-converting enzyme 2 (ACE2), and reducing transmembrane serine protease 2 (TMPRSS2) and cathepsin L (CTSL) activity. Then, we used the method of "Here" (HRMS-exploring-recombination-examining) and found that isochlorogenic acid A, B, and C of coffee ingredients showed their potential to inhibit SARS-CoV-2 infection (inhibitory efficiency 43–54%). In addition, decaffeinated coffee still preserves inhibitory activity against SARS-CoV-2. Finally, in a human trial of 64 subjects, we identified that coffee consumption (approximately 1–2 cups/day) is sufficient to inhibit infection of multiple variants of SARS-CoV-2 entry, suggesting coffee could be a dietary strategy to prevent SARS-CoV2 infection. Conclusions This study verified moderate coffee consumption, including decaffeination, can provide a new guideline for the prevention of SARS-CoV-2. Based on the results, we also suggest a coffee-drinking plan for people to prevent infection in the post-COVID-19 era.
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  • EmergMemeHologram@startrek.website
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    2 years ago

    This study verified moderate coffee consumption, including decaffeination, can provide a new guideline for the prevention of SARS-CoV-2. Based on the results, we also suggest a coffee-drinking plan for people to prevent infection in the post-COVID-19 era.

    Aw heck yes, petition to name this the Janeway diet!

    • PlasmaDistortion@lemm.ee
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      2 years ago

      In the words on the great Janeway, “Do It!”.

      • EmergMemeHologram@startrek.website
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        2 years ago

        There’s coffee an odds ratio decrease of 0.1 in that nebula!

  • D3FNC [any]@hexbear.net
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    2 years ago

    Nicotine and amphetamines had the same effect based on studies done during the pandemic, accounting for smoking’s oddly protective effect that was observed initially, counterintuitively.

    As someone with ADHD that dips and drinks coffee, none of that stopped me from getting covid repeatedly while working in a hospital.

    • sovietknuckles [they/them]@hexbear.net
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      2 years ago

      Still getting COVID is consistent with the results of this study. Coffee helps, but only by 10%.

      Based on the previous report analysis [26], drinking one or more cups of coffee per day was related to approximately 10% lower risk of COVID-19 compared to no coffee in the UK Biobank (UKB)

  • Posadist_Paladin [they/them]@hexbear.net
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    2 years ago

    hell yeah coffee and weed have ace2 inhibitors just what i need to hear to keep enjoying them guilt free baby

  • Venus [she/her]@hexbear.net
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    2 years ago

    Is this actually true in the way that is intuitive or is it true in the same sense that if you have a petri dish with cancerous cells in it you can kill them with a handgun

    • ☆ Yσɠƚԋσʂ ☆@lemmy.mlOP
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      2 years ago

      According to the study at least, they claim to have seen a statistically significant difference in human trials with moderate coffee consumption. Whether the trials were well done is another question of course. :)

  • Variants of Concern
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    2 years ago

    Good news everyone

  • YurkshireLad@lemmy.ca
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    2 years ago

    That site won’t let me reject cookies, I’m forced to accept them. So I’ll pass thanks.

    • Mothra@mander.xyz
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      2 years ago

      Well coffee and cookies go great together

    • online@lemmy.ml
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      2 years ago

      If you use Firefox you can turn on the thing that they just enabled in Germany by going to about:config and setting these options:

      • cookiebanners.service.mode 2
      • cookiebanners.service.mode.privateBrowsing 2

      They are both set to ‘0’ right now.

      They are testing this setting, so if something goes wrong then change it back.

      More information here: https://community.mozilla.org/en/campaigns/firefox-cookie-banner-handling/

      Caveat: I just learned this on Lemmy in some other thread I can’t find again.

  • GorbinOutOverHere [comrade/them]@hexbear.net
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    2 years ago

    CBD also helps and doesn’t leave a motherfucker with the jitters

    • GarbageShoot [he/him]@hexbear.net
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      2 years ago

      Is that true? I don’t do anything but I’d see about this if it kept my lungs from turning into beef jerky

      • fox [comrade/them]@hexbear.net
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        2 years ago

        It won’t stop an infection from going bad but it can mildly reduce risk of infection iirc

  • Chais@sh.itjust.works
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    2 years ago

    So between daily coffee and weekly cannabis consumption I should be well protected. Not to mention the vaccination. So why did I catch that shit last year??

    • EmergMemeHologram@startrek.website
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      2 years ago

      Because 10% more protection does not mean 100% safe.

      • Chais@sh.itjust.works
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        2 years ago

        I wasn’t being serious, in case that wasn’t obvious. But thanks for the clarification.

        • EmergMemeHologram@startrek.website
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          2 years ago

          I’ve lost my sarcasm detector when it comes to Covid 😑

          • Chais@sh.itjust.works
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            2 years ago

            That’s understandable.

    • Pascal Wicht@mastodon.social
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      2 years ago

      @Chais @yogthos I was asking myself the same 🤣

  • sooper_dooper_roofer [none/use name]@hexbear.net
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    2 years ago

    Anyone else get a feeling of pressure in their eye when they drink coffee?

    It happens to me sometimes but not always
    that’s why i stopped

    • joranvar@feddit.nl
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      2 years ago

      Do you remove the spoon from the cup, before you take a sip? /j

    • Microplasticbrain@lemm.ee
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      2 years ago

      I would see an optometrist to check your eye pressure to prevent glaucoma to be safe.

    • EmergMemeHologram@startrek.website
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      2 years ago

      I do not, but does that happen with decaf or with other caffeinated drinks?

      • sooper_dooper_roofer [none/use name]@hexbear.net
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        2 years ago

        happens with decaf, doesn’t happen with tea

        it has nothing to do with caffeine

        • EmergMemeHologram@startrek.website
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          That’s strange. The body is weird

          I had a friend who drank a case of Coke a day and then had a mini heart attack at 18 and now he can’t have any caffeine or he gets sick.

          • sooper_dooper_roofer [none/use name]@hexbear.net
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            2 years ago

            how many cans is a case?

            • EmergMemeHologram@startrek.website
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              2 years ago

              I don’t know, those two wide ones where the front pulled down as a dispenser.

              I haven’t bought coke in decades so I couldn’t tell you.

  • FALGSConaut [comrade/them]@hexbear.net
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    2 years ago

    I’m only half joking when I credit caffeine and cannabis for helping me dodge covid all this time (that I know of, I might’ve had an asymptomatic case but every time I’ve gotten tested it’s been negative). Of course masking and living like a hermit even before covid kicked off definitely helps, but I’ll take the excuse to indulge in my favourite vices

    • The£0b°t°m¡§t@lemmy.dbzer0.com
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      2 years ago

      I heard beer helps a lot too!

      Where I heard you ask? Well I red it somewhere… I’m sure it was a reliable source…

  • anonochronomus [comrade/them, she/her]@hexbear.net
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    2 years ago

    I was at an inpatient medical facility last year and they had a doctor come in specifically to give an hour long lecture about how smoking cigarettes prevents covid. It was the most surreal thing I’ve ever experienced and I have no idea where they found that Marlboro man ass doctor.

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