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☆ Yσɠƚԋσʂ ☆@lemmy.ml to Science@lemmy.mlEnglish · 2 years ago

Study finds coffee inhibits SARS-CoV-2

cellandbioscience.biomedcentral.com

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Study finds coffee inhibits SARS-CoV-2

cellandbioscience.biomedcentral.com

☆ Yσɠƚԋσʂ ☆@lemmy.ml to Science@lemmy.mlEnglish · 2 years ago
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Coffee as a dietary strategy to prevent SARS-CoV-2 infection - Cell & Bioscience
cellandbioscience.biomedcentral.com
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Background To date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2 infection becomes an interesting issue on a daily basis. Coffee consumption is connected with reduced COVID-19 risk and correlated to COVID-19 severity. However, the mechanisms of coffee for the reduction of COVID-19 risk are still unclear. Results Here, we identified that coffee can inhibit multiple variants of the SARS-CoV-2 infection by restraining the binding of the SARS-CoV-2 spike protein to human angiotensin-converting enzyme 2 (ACE2), and reducing transmembrane serine protease 2 (TMPRSS2) and cathepsin L (CTSL) activity. Then, we used the method of "Here" (HRMS-exploring-recombination-examining) and found that isochlorogenic acid A, B, and C of coffee ingredients showed their potential to inhibit SARS-CoV-2 infection (inhibitory efficiency 43–54%). In addition, decaffeinated coffee still preserves inhibitory activity against SARS-CoV-2. Finally, in a human trial of 64 subjects, we identified that coffee consumption (approximately 1–2 cups/day) is sufficient to inhibit infection of multiple variants of SARS-CoV-2 entry, suggesting coffee could be a dietary strategy to prevent SARS-CoV2 infection. Conclusions This study verified moderate coffee consumption, including decaffeination, can provide a new guideline for the prevention of SARS-CoV-2. Based on the results, we also suggest a coffee-drinking plan for people to prevent infection in the post-COVID-19 era.
  • sooper_dooper_roofer [none/use name]@hexbear.net
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    2 years ago

    Anyone else get a feeling of pressure in their eye when they drink coffee?

    It happens to me sometimes but not always
    that’s why i stopped

    • joranvar@feddit.nl
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      2 years ago

      Do you remove the spoon from the cup, before you take a sip? /j

    • Microplasticbrain@lemm.ee
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      2 years ago

      I would see an optometrist to check your eye pressure to prevent glaucoma to be safe.

    • EmergMemeHologram@startrek.website
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      2 years ago

      I do not, but does that happen with decaf or with other caffeinated drinks?

      • sooper_dooper_roofer [none/use name]@hexbear.net
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        2 years ago

        happens with decaf, doesn’t happen with tea

        it has nothing to do with caffeine

        • EmergMemeHologram@startrek.website
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          2 years ago

          That’s strange. The body is weird

          I had a friend who drank a case of Coke a day and then had a mini heart attack at 18 and now he can’t have any caffeine or he gets sick.

          • sooper_dooper_roofer [none/use name]@hexbear.net
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            2 years ago

            how many cans is a case?

            • EmergMemeHologram@startrek.website
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              2 years ago

              I don’t know, those two wide ones where the front pulled down as a dispenser.

              I haven’t bought coke in decades so I couldn’t tell you.

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