The regulation calls out 19 vehicle functions which must have physical controls inside the vehicle, with additional requirements about size and usability of the buttons.
Those functions include:
Turn signals
Hazard lights
Horn
PRND gear shifter
Driver assist function, if present
Windshield wipers
Windshield defroster
Power windows
Emergency call system
Power off switch for EVs


Assuming the car is toasty hot when I get in, I probably want to set the AC to a lower target temp than normal to get it cooling faster. This would necessitate changes later once the cabin has reached a more comfy level.