Biochemistry and the respective pathways are mindbendingly awesome and at the same time you really have to get into a special way of thinking while amassing loads of knowledge to get it.
During a seminar dealing with cell structures and mechanisms i held a short presentation (45min) regarding the golgi apparatus and the techniques it uses to create diverse modifications of biomolecules, and how it fits in with what is seen on the cell surface itself. Researching this thematic complex really changed my understanding of how all that stuff really works - just learning “basic” organic chemistry did not help in giving me a more intuitive understanding how all these myriads of steps really happen. If those two areas had been intertwined somehow, i wouldnt have had to take my OrgChem exam 3 times to pass (it was notoriously difficult at my uni with an average of 20% of students passing per attempt lol - although i was sooo close at the second attempt)
yup is pretty interesting, my nnew awwtistic obession aaaaaaaaaaawawawaawawawawawawawawa aslkajdfljaf
That’s a great autistic obsession kittygirl, you will never stop to be astounded, because we all are still learning new stuff every day and i don’t think that will stop in the next decades lol
Somewhat relevant:
theCrux - Deep dive videos on cellular mechanisms. Not exactly biochem stuff, but adjacent. More like where all those enzymes come from.
wait tell me more. what is this “golgi apparatus” that you’re speaking of?
The Golgi apparatus is an cell organelle, and it’s function can be best described as an hybrid between an assembly line and a logistics center. It sits close to the nucleus, and is needed to modify proteins into glycoproteins (proteins with different sugars attached) and then to transport these to the cell surface for integration into the cell membrane.
It consists of a stack of chambers made out of lipid membranes, and by the magic of having a different pH and different enzymes in the chambers, can selectively attach a “tree” of different sugars onto proteins. One important thing everyone has heard of that gets constructed here is the blood type! It depends on if only a basic sugar structure (0), or one or both of the attachments (A, B, AB) are attached onto surface proteins.
Something else that gets done here is the creation of “location tags”, which are used as a shipping label and to make sure that proteins are brought to the correct destination in the cell; you want to make sure your proton pumps for integration in lysosomes (which need a very low pH to help with degradation of all the stuff the cell doesn’t wanna deal with) really land at lysosomes and not for example the cell membrane.
It also provides the “transport vehicles”, the so called vesicles. They are created by budding off of the Golgi membrane, creating little lipid bubbles which contain the membrane-bound cargo and the shipping labels. These vesicles are also what is used for cell secretion, simply by merging with the cell wall and emptying their contents to the exterior when merging.
This is only a short overview - there’s a lot more going on than i want to put in a comment here. As always, https://en.wikipedia.org/wiki/Golgi_apparatus is a good starting point; i learnt most of what i know about this from Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter - Molecular Biology of the Cell
very fascinating stuff. i must admit that i’ve looked way too little into it so far.
It is fascinating, and it is mindbogglingly complex to boot. But if you are interested in cell biology in general, i can really recommend the book i referenced. I’ll send you a DM with a link if you wanna take a look.
hmm, i’m gonna read up on the biochemical basics first i think.
too late lol, already sent you the link, now you will be hooked. I really liked the book - at least my older edition was taking care that it was still understandable
thank you :)
you know, i’m currently writing a series of articles about the fundamentals of biochemistry and genetics as well. i already have a few articles but they’re mostly in german.
for example: consider how important gene regulation is: in every complex organism, there’s different cell types because each cell is regulated. so, most of the function of each cell is regulated, and regulation is not a small phenomenon but one that makes the cell what it is, so a rather significant part. yet it often comes short in many books about cellular biology.
Yeah, organic chemistry is a fucker.
But it’s awesome too - seeing how all of this complexity was created out of chaos; how changes on a molecular basis are able to give a competitive advantage in macroscopic ways and driving evolution this way; it’s simply fascinating. I’m pretty sad i never got to work in the field, but at least i kept my enthusiasm about all of this wonderful, super complex simplicity.
nyaaaaa my mom have it(adrenal source), have a lot troubles with it, i think i might have too, awawawawawawawawawa
Biology is really just chemistry after four billion years of bumping random shit together. All of this is just 4 rings with random H’s, O’s or OH’s placed around.
I love the naming sometimes. Add an OH group somewhere to 5a-Dihydroprogresterone? Now it’s called 5a-Pregnan-17a-ol-3,20-dione because we ran out of new names to give.
chemical computers
Wow thanks so much, that’s totally very useful and applicable for me to use myself and stuff (whatever this is)
I tought progresterone could turn into DHT
yup, mainly if do it thru liver, but also thru 5a its turns into neurosteroid - allopregnanolone, and yeah i feel this effect, but taking 5a inhibitors like finasteride will numb allopregnanolone synthesis as well, i wanna try bicalutamide to numb androgen receptors, some androgens have direct neurosteroid effect without AR
Im not verry educated on this topic but i saw somewhere that progresteron lowers androgen production if thats true would taking a load of prog block the conversion from prog to dht and other androgen metabolites (sorry for bad english i hope im understanable)
prog will supress hpg axis, so suppressing luterizing hormone will stunt gonadal production, but taking prog orally will def create dht backdoor, and also mental side effect due too much conversion to allopregnanolone neurosteroid by same 5a reductase action, so taking rectally is better option, as well better levels of prog itself
Woaw it took 4 doctors and a stranger online before i got a good awnser thanks
nyaaaa tyy, yup im smart, also i now hyperfocused on this topic
Wiki pathways?
![androgen backdoor [rule]way](https://piefed.cdn.blahaj.zone/posts/hW/9v/hW9vnkEtCsCcY1A.png){kind=link}